PI-3065CAS号： 955977-50-1分子式： C27H31FN6OS分子量： 506.64描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
PI3065
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| 外观 |
White to off white powder
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| 可溶性/溶解性 |
DMSO : 25 mg/mL (49.34 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
p110α；p110β；p110δ
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| In vitro(体外研究) |
PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ.
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| In vivo(体内研究) |
PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss.
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分子结构图
