IDH-305CAS号： 1628805-46-8分子式： C23H22F4N6O2分子量： 490.45描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO : ≥ 150 mg/mL (305.84 mM)
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| 生物活性 | |
| 靶点 |
IDH
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| In vitro(体外研究) |
IDH-305 inhibits HCT116-IDH1R132H+/- cells with an IC50 of 24 nM.
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| In vivo(体内研究) |
IDH-305 (30-300 mg/kg; p.o.; twice daily for 21 days) inhibits 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model.
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分子结构图
