BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:100 mg/mL (155.36 mM)

neuropeptide Y (NPY) Y1 receptor:0.38 nM(human), neuropeptide Y (NPY) Y1 receptor:0.72 nM (rat)

BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding response mediated by 1 μg NPY. BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting [1]. BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels [2].