ML-297CAS号： 1443246-62-5分子式： C17H14F2N4O分子量： 328.3描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
CID-56642816；VU0456810
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| 外观 |
white to beige powder
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| 可溶性/溶解性 |
DMSO ：66 mg/mL (201.02 mM)
Ethanol ：15 mg/mL (45.69 mM) |
| 生物活性 | |
| 靶点 |
GIRK1/2；GIRK1/4
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| In vitro(体外研究) |
ML 297 is completely inactive for GIRK2/3.
ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3. |
| In vivo(体内研究) |
ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment.
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分子结构图
