TH287CAS号： 1609960-30-6分子式： C11H10Cl2N4分子量： 269.13描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.
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| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
TH287,TH-287
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 53 mg/mL (196.93 mM)
Ethanol 10 mg/mL warmed (37.15 mM) |
| 生物活性 | |
| 靶点 |
MTH1
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| In vitro(体外研究) |
TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage.
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| In vivo(体内研究) |
In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82μM.
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分子结构图
