LY 456236 HydrochlorideCAS号： 338736-46-2分子式： C16H16ClN3O2分子量： 317.77描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LY 456236 hydrochloride is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:225.0 mg/mL (708.1 mM)
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| 生物活性 | |
| 靶点 |
EGFR:0.91 μM, mGlu1:0.145 μM
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| In vitro(体外研究) |
LY456236 (2 μM; 30 min) reduces the proliferation of OCCM-30 cells stimulated by DHPG .[1]
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| In vivo(体内研究) |
LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).[2]
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