CC-223CAS号： 1228013-30-6分子式： C21H27N5O3分子量： 397.47描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
CC-223 is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2. |
| 纯度 |
99%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
体外:
DMSO 79mg/mL(198.75mM) Ethanol 79mg/mL(198.75mM) Water <1mg> |
| 生物活性 | |
| 靶点 |
mTOR ,cFMS ,FLT4 ,DNA-PK
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| In vitro(体外研究) |
In a panel of cell lines, CC-223 inhibits both mTORC1 (S6RP and 4EBP1) and mTORC2 markers with IC50 ranges of 27 to 184 nM for pS6RP, 120 to 1,050 nM for p4EBP1 and 11 to 150 nM for pAKT(S473), respectively. CC-223 also inhibits cell growth and induces apoptosis across a number of cancer cell lines.
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| In vivo(体内研究) |
In PC-3 tumor-bearing mice, CC-223 (25 mg/kg, p.o.) inhibits both mTORC1 and mTORC2. CC-223 (25 mg/kg, p.o.) also results in tumor growth inhibition by 47% to 95% in xenograft models of prostate, glioma, breast, lung, and colon.
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| 参考文献 | |
| 参考文献 |
[1] Mortensen DS, et al. Mol Cancer Ther. 2015, 14(6), 1295-1305. |
分子结构图
