Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3

Human

HEK293

35-45 kDa(Reducing)

Lyophilized Powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH7.4.

Gly17-Gln208

C-10His

＞95% by SDS-PAGE&RP-HPLC

＜0.1 EU/μg(gel-clot)

unconjugated

Centrifuge tubes before opening.Reconstitute no more than 1 mg/mL according to the size in deionized water.

Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

IgG Fc region receptors (FcγRs) are members of the Ig superfamily and play a role in activating or inhibiting immune responses. Human FcγRs can be divided into 3 classes: RI (CD64), RII (CD32) and RIII (CD16). CD16 is a low affinity Fc receptor and has been identified as Fc receptors FcγRIII (a (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies and are composed of two different The highly homologous gene of CD16a is encoded in a cell-type-specific manner. In humans, CD16a is a 50-70 kDa type I transmembrane activating receptor that is found in NK cells, T cells, monocytes and macrophages Expression, involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes.Aberrant expression or mutation of CD16a is associated with viral infection, systemic lupus erythematosus and alloimmune neonatal neutropenia susceptibility. In humans, the mutation of a single amino acid of CD16a may affect the susceptibility of autoimmune diseases or the response to therapeutic IgG antibodies. This product is recombinantly expressed human Fc γ RIIIa from HEK293 cell line, purified, removed Bacterial filter packs and freeze-dried.

P08637-1