MI-192 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC2 (IC₅₀ = 30 nM) and HDAC3 (IC₅₀ = 16 nM) over HDAC1, 4, 6, 7, and 8 (IC₅₀s = 4.8, 5, >10, 4.1, and >10 μM, respectively).¹ At 0.1-0.4 μM, it induces differentiation and promotes apoptosis of acute myeloid leukemic cell lines U937, HL60, and Kasumi-1.¹

≥98%

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1.Boissinot, M.,Inman, M.,Hempshall, A., et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leukemia Research 36, 1304-1310 (2012).