AZ191CAS号： 1594092-37-1分子式： C24H27N7O分子量： 429.52描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
AZ-191,AZ 191
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 86 mg/mL (200.22 mM)
Ethanol 1 mg/mL (2.32 mM) |
| 生物活性 | |
| 靶点 |
DYRK1B ,DYRK1A
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| In vitro(体外研究) |
AZ191 selectively inhibits DYRK1B serine/threonine kinase activity with no effect on tyrosine kinase autophosphorylation. In HEK-293 cells, AZ191 also displays much greater potency for DYRK1B over DYRK1A, inhibiting CCND1 phosphorylation. In HD1B cells, AZ191 strongly inhibits the levels of the cell-cycle regulators, p21Cip1 and p27Kip1, and increases cell-cycle progression.
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分子结构图
