GPR55 is a G protein-coupled receptor that has been described as a cannabinoid (CB) receptor, although it also responds to other ligands, including lysophosphatidylinositol (LPI).^1,2,3 ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC₅₀ = 328 nM) and blocks receptor-dependent translocation of PKCβII when used at a concentration of 30 µM.⁴

≥98%

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1.Lauckner, J.E.,Jensen, J.B.,Chen, H.Y., et al. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proceedings of the National Academy of Sciences of the United States of America 105(7), 2699-2704 (2008).

2.Ryberg, E.,Larsson, N.,Sjögren, S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor. British Journal of Pharmacology 152, 1092-1101 (2007).

3.Oka, S.,Nakajima, K.,Yamashita, A., et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochemical and Biophysical Research Communications 362, 928-934 (2007).

4.Heynen-Genel, S.,Dahl, R.,Shi, S., et al. Selective GPR55 antagonists: Screening for selective ligands for GPR55. 1-26 (2010).