BML-190CAS号： 2854-32-2分子式： C23H23ClN2O4分子量： 426.89描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
BML-190 is an indomethacin morpholinylamide which functions as a selective inverse agonist of the human cannabinoid CB2 receptor. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
BML 190, BML190, IMMA, Indomethacin morpholinylamide
|
| 外观 |
类白色粉末
|
| 可溶性/溶解性 |
DMSO : 21 mg/mL (49.2 mM)
|
| 生物活性 | |
| 靶点 |
CB2
|
| In vitro(体外研究) |
BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction.
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分子结构图
