AP1189 AcetateCAS号： 959850-74-9分子式： C16H18N6O4分子量： 358.35描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:50 mg/mL (139.53 mM)
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| 生物活性 | |
| In vitro(体外研究) |
Added to macrophage cultures, AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes[1].
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| In vivo(体内研究) |
Oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ～3-fold[1].
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