PF-04418948CAS号： 1078166-57-0分子式： C23H20FNO5分子量： 409.41描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
PF04418948；PF 04418948
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| 外观 |
white to beige powder
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| 可溶性/溶解性 |
DMSO : 130 mg/mL (317.53 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
EP₂ receptor
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| In vitro(体外研究) |
PF-04418948 antagonizes the effects of butaprost and PGE2 on an EFS-induced contraction of the human myometrium, and antagonizes PGE2-induced relaxation of carbachol pre-contracted rings of mouse trachea. PF-04418948 competitively inhibits relaxations of murine and guinea pig trachea induced by ONO-AE1-259 and PGE2 respectively. PF-04418948 restores neutrophil extracellular traps (NETs) formation in neutrophils isolated from BMT mice or HSCT patients.
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| In vivo(体内研究) |
In Rats, PF-04418948 (10 mg/kg, p.o.) reduces the mean cutaneous blood flow peak response and AUC0–60 by 41% and 61%, respectively.
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分子结构图
