KPT-185CAS号： 1333151-73-7分子式： C16H16F3N3O3分子量： 355.31描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
KPT-185 is a selective CRM1 inhibitor. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
KPT185；KPT 185
|
| 可溶性/溶解性 |
Ethanol ：66 mg/mL (185.8 mM)
DMSO ：66 mg/mL (185.8 mM) |
| 生物活性 | |
| 靶点 |
CRM1
|
| In vitro(体外研究) |
KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. KPT-185 reduces CRM1 protein protein level and shows a significant nuclear accumulation of CRM1 cargo proteins. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells.
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分子结构图
