C-176CAS号： 314054-00-7分子式： C11H7IN2O4分子量： 358.09描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
C-176 is a strong and covalent mouse STING inhibitor.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
C-176 STING inhibitor
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| 可溶性/溶解性 |
DMSO : 125 mg/mL (349.07 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
STING
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| In vitro(体外研究) |
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
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| In vivo(体内研究) |
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice. C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1−/− mice.
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分子结构图
