Bis(methylthio)gliotoxin (FR-49175)CAS号： 74149-38-5分子式： C15H20N2O4S2分子量： 356.5描述应用纯度储存/保存方法形态外观密度熔点沸点折射率PK值可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.
|
| 应用 |
An antiphagocytic metabolite
|
| 纯度 |
99%
|
| 储存/保存方法 |
Store at -20° C
|
| 形态 |
Solid
|
| 基本信息 | |
| 外观 |
Oil
|
| 密度 |
~1.50 g/cm3 (Predicted)
|
| 熔点 |
243.32° C (Predicted)
|
| 沸点 |
~669.6° C at 760 mmHg (Predicted)
|
| 折射率 |
n20D 1.70
|
| PK值 |
pKa: 12.7 (Predicted)
|
| 可溶性/溶解性 |
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml), and water (Partly miscible).
|
| MDL |
MFCD00133146
|
| PubChem CID |
194564
|