CFTRinh 172 (CFTR Inhibitor-172)CAS号： 307510-92-5分子式： C18H10F3NO3S2分子量： 409.4描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
CFTR Inhibitor-172; CFTRinh-172
|
| 外观 |
黄色粉末
|
| 可溶性/溶解性 |
DMSO : 40.9 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
CFTR
|
| In vitro(体外研究) |
CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I- transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl− current in the rabbit acinar and duct cells of rabbit lacrimal gland. CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition.
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| In vivo(体内研究) |
CFTRinh-172 (20 µg/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo.
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分子结构图
