L-168049CAS号： 191034-25-0分子式： C24H20BrClN2O分子量： 467.79描述纯度储存/保存方法别名外观密度熔点沸点折射率IC50PK值可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
L-168049 is a potent, selective and non-competitive antagonist of the human glucagon receptor (hGR). It binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively).
|
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
L-168,049
|
| 外观 |
Light beige solid
|
| 密度 |
1.37 g/cm3 (Predicted)
|
| 熔点 |
256.88° C (Predicted)
|
| 沸点 |
542.33° C at 760 mmHg (Predicted)
|
| 折射率 |
n20D 1.63 (Predicted)
|
| IC50 |
Human GR: IC50 = 3.7 nM; Glucagon receptor: IC50 = 37 nM (mouse); Glucagon-stimulated cAMP synthesis in CHO cells expressing hGR: IC50 = 41 nM; Canine GR: IC50 = 60 nM; Murine GR: IC50 = 63 nM
|
| PK值 |
pKa: 13.99 (Predicted), pKb: 5.48 (Predicted)
|
| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and ethanol (100 mM).
|
| MDL |
MFCD08703112
|
| PubChem CID |
5311276
|
分子结构图
