PKI-166CAS号： 187724-61-4分子式： C20H18N4O分子量： 330.38描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PKI-166 is an oral inhibitor of EGF-R tyrosine kinase (IC50:0.7 nM) that is both effective and selective. PKI-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cancer.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:27.5 mg/mL (83.23 mM)
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| 生物活性 | |
| 靶点 |
EGFR tyrosine kinase:0.7 nM
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| In vitro(体外研究) |
PKI-166 (0–0.5 μM; 1 hour) pretreatment suppresses EGFR autophosphorylation in human pancreatic cancer cells. PKI-166 (0.03μ M; 6 days) increased the cytotoxicity mediated by gemcitabine.[1]
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| In vivo(体内研究) |
PKI-166 (100 mg/kg; p.o.; daily; day 7-day 35 after xenograft) suppresses the growth of pancreatic cancer.[1]
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