TD-165CAS号： 2305936-56-3分子式： C46H59N7O8S分子量： 870.07描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group[1].
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:40 mg/mL (110.38 mM)
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| 生物活性 | |
| 靶点 |
cereblon:20.4 nM (DC50)
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| In vitro(体外研究) |
Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells[1]. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%[1].
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