L-161,982CAS号： 147776-06-5分子式： C32H29F3N4O4S2分子量： 654.72描述应用纯度储存/保存方法形态密度折射率IC50PK值Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
L-161,982 is an EP4 (EP4 receptor) antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively).
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| 应用 |
An EP4 receptor antagonist
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| 纯度 |
>99%
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| 储存/保存方法 |
Store at 4℃,2 years.
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| 形态 |
Solid
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| 基本信息 | |
| 密度 |
1.37 g/cm3 (Predicted)
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| 折射率 |
n20D 1.63 (Predicted)
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| IC50 |
AT1: IC50 = 0.81 nM (human); Angiotensin II type 2 receptor: IC50 = 80 nM (rat)
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| PK值 |
pKa: 4.57 (Predicted), pKb: 2.1 (Predicted)
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| Ki 数据 |
EP4: Ki= 3.16 nM (human); TXA2R: Ki= 0.71 µM (human); EP3: Ki= 1.90 µM (human); DP: Ki= 5.10 µM (human); PGF2Rα: Ki= 5.63 µM (human)
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| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and DMF (~10 mg/ml).
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| MDL |
MFCD09959710
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| PubChem CID |
9961192
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