UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB₂ receptor (K_i = 1.8 nM) over the central CB₁ receptor (K_i = 150 nM).¹ (±)-UR-144 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.^2,3 It is possible that this metabolite may be detectable in either serum or urine.^2,3 The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.

≥98%

Store at -20℃

1.Frost, J.M.,Dart, M.J.,Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity. Journal of Medicinal Chemistry 53, 295-315 (2010).

2.Wintermeyer, A.,Möller, I.,Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH 018. Analytical and Bioanalytical Chemistry 398, 2141-2153 (2010).

3.Chimalakonda, K.C.,Moran, C.L.,Kennedy, P.D., et al. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH 018 and JWH 073 in human urine. Analytical Chemistry 83(16), 6381-6388 (2011).