UR-144  is a synthetic cannabinoid (CB) analog of JWH 018 in which the naphthalene ring is substituted with a tetramethylcyclopropyl group. This substitution results in a compound which is a potent agonist for the peripheral CB₂ receptor.¹ UR-144 Degradant is a common impurity observed during GC-MS analysis of samples containing UR-144. The opened ring of the degradant is presumed to be produced during heating of UR-144. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.²

≥98%

Store at -20℃

KM-X1 Degradant;UR-144 3,3,4-Trimethylpentenoyl isomer;

1.Frost, J.M.,Dart, M.J.,Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity. Journal of Medicinal Chemistry 53, 295-315 (2010).

2.McLafferty, F.W. Mass spectrometric analysis. Molecular rearrangements. Analytical Chemistry 31(1), 82-87 (1959).