AGI-14100CAS号： 1448346-43-7分子式： C29H22ClF4N5O3分子量： 599.96描述纯度储存/保存方法靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 生物活性 | |
| 靶点 |
HT1080 chondrosarcoma cell line:1 nM, mIDH1-R132H homodimer:6 nM
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| In vivo(体内研究) |
AGI-14100 (50 mg/kg; oral; single; female nude BALB/c mice) inhibition robust tumor 2-HG was achieved 12 hours post-dose demonstrating desirable in vivo results.[1]
AGI-14100 had decent oral pharmacokinetics (PK) properties in rats (F =44 %), dogs (F =18 %), and cynomolgus monkeys (F =43 %).[1] |