ML-141CAS号： 71203-35-5分子式： C22H21N3O3S分子量： 407.49描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
ML141；ML 141；CID-2950007
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| 外观 |
white to beige Powder
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| 可溶性/溶解性 |
DMSO : ≥ 55 mg/mL (134.97 mM)
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| 生物活性 | |
| 靶点 |
cdc42
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| In vitro(体外研究) |
ML141 enhances the ability of TMX to suppress BLBC cell growth through both induction of cell death and suppression of cell division. ML141 also significantly protects neuroblastoma cells from metformin-induced apoptosis. Moreover, ML141 diminishes K. pneumoniae invasion in a dose-dependent manner.
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| In vivo(体内研究) |
In NOD/SCID mice bearing MDA-MB 231 derived tumors, ML141 (1 mg/day i.p.), via inhibition of Cdc42, enables TMX to suppress growth of MDA-MB 231 derived tumors. In addition, ML141 (10 mg/kg i.p.) enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization in mice.
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分子结构图
