BMS-833923(XL-139)CAS号： 1059734-66-5分子式： C30H27N5O分子量： 473.57描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.
|
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
BMS 833923; BMS833923; XL-139; XL139; XL 139
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO 95 mg/mL (200.6 mM)
|
| 生物活性 | |
| 靶点 |
Smoothened
|
| In vitro(体外研究) |
BMS-833923 reduces hedgehog pathway activity, decreases cell proliferation and induces apoptosis via the intrinsic pathway in esophageal adenocarcinoma (EAC) cell lines. BMS-833923 dose-dependently affects canonical and prostate hedgehog signature gene transcription in vitro.
|
分子结构图
