AR-13324 hydrochlorideCAS号： 1253952-02-1分子式： C28H29Cl2N3O3分子量： 526.45描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
AR-13324是ROCK抑制剂，Ki值为0.2-10.3 nM。 |
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
奈他地尔;Netarsudil hydrochloride；Netarsudil (AR-13324) 2HCl
|
| 外观 |
White to off white powder
|
| 可溶性/溶解性 |
DMSO ：20 mg/mL (37.99 mM)
|
| 生物活性 | |
| 靶点 |
ROCK
|
| In vitro(体外研究) |
Previous study showed that at the cellular level, netarsudil had been shown to be able to induce loss of actin stress fibers, cell shape changes, loss of focal adhesions, as well as changes in extracellular matrix composition of TM cells.
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| In vivo(体内研究) |
Animal efficacy study found that the topical treatment of netarsudil was able to affect both proximal (trabecular meshwork and Schlemm’s Canal) and distal portions (intrascleral vessels) of the mouse conventional outflow tract.
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分子结构图
