LDN-212854CAS号： 1432597-26-6分子式： C25H22N6分子量： 406.48描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
BMP Inhibitor III；LDN212854；LDN 212854
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| 外观 |
white to beige Powder
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| 可溶性/溶解性 |
DMSO : ≥ 30 mg/mL (73.80 mM)
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| 生物活性 | |
| 靶点 |
ALK2 ,ALK1 ,ALK3 ,ALK4 ,ALK5
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| In vitro(体外研究) |
In myofibroblast C2C12 cells, LDN-212854 exhibits greater selectivity for BMP6- versus BMP4-induced osteogenic differentiation.
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| In vivo(体内研究) |
LDN-212854 (6 mg/kg, i.p.) effectively neutralize ALK2 signaling in vivo, and potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.
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分子结构图
