MG-115 is a potent, reversible proteasome inhibitor. MG-115 specifically inhibits the chymotrypsin-like activity of the proteasome. MG-115 is an inhibitor of 20S Proteasome and 26S Proteasome. It has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

MG115；MG 115；Z-Leu-Leu-Norvalinal

white Ppowder

1.08 g/cm³ (Predicted)

278.81° C (Predicted)

678.79° C at 760 mmHg (Predicted)

n²⁰_D 1.51 (Predicted)

20S proteasome: K_i= 21 nM; 26S proteasome: K_i= 35 nM

Soluble in DMSO (50 mg/ml), and methanol (1 mg/ml).

9868928