APX-115 free baseCAS号： 1270084-92-8分子式： C17H17N3O 分子量： 279.34描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase （Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
Ewha-18278 free base
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| 可溶性/溶解性 |
DMSO : 250 mg/mL (894.97 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
Nox1；Nox2；Nox4(ki)
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| In vitro(体外研究) |
In the mouse podocyte cell line, APX-115 free base (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 free base attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes.
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| In vivo(体内研究) |
APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice.
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分子结构图
