CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.

An inhibitor of Tubulin polymerization

≥95%

Store at -20° C

Solid

1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone

~1.3 g/cm³ (Predicted)

196.39° C (Predicted)

~498.5° C at 760 mmHg (Predicted)

n²⁰_D 1.72 (Predicted)

pK_b: 0.96 (Predicted)

Soluble in DMSO (12 mg/ml).

MFCD08277043

404353