Idelalisib (CAL-101)CAS号： 870281-82-6分子式： C22H18FN7O分子量： 415.42描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
Idelalisib; CAL-101, GS-1101; GS 1101; GS1101,CAL101
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
Ethanol ：22 mg/mL (53 mM)
DMSO ：77 mg/mL (185.4 mM) |
| 生物活性 | |
| 靶点 |
PI3K
|
| In vivo(体内研究) |
A significant reduction is observed in the CD11b+Ly6G+ neutrophils from brain homogenates of bothp110δD910A/D910A mice and CAL-101 (40 mg/kg, i.v.) post-treated mice.
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分子结构图
