CI-994CAS号： 112522-64-2分子式： C15H15N3O2分子量： 269.3描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
乙酰地那林；Acetyldinaline; Tacedinaline; PD 123654; Goe 5549
|
| 外观 |
off-white Powder
|
| 可溶性/溶解性 |
DMSO : 26.9 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
HDAC1 ,HDAC2 ,HDAC3
|
| In vitro(体外研究) |
CI-994 ( CI-994 inhibits growth of LNCaP cell with IC50 of 7.4 μM. CI-994 exerts activity against several tumor cell lines with greater cytotoxicity against the solid tumors relative to both the leukemia and normal fibroblast cell lines. CI-994 inhibits growth of rat leukemia BCLO cells with IC50 of 2.5 μM.
|
| In vivo(体内研究) |
CI-994 exerts demonstrated antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.
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分子结构图
