Epigallocatechin GallateCAS号: 989-51-5分子式: C22H18O11分子量: 458.37描述应用纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. |
应用 |
An inhibitor of Bcl-2 and NOS2
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纯度 |
≥98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
EGCG; Teavigo; Tea catechin;(-)-Epigallocatechin Gallate
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外观 |
white powder
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可溶性/溶解性 |
Ethanol :45.8 mg/mL (100 mM)
DMSO :4.6 mg/mL (10 mM) Water :4.6 mg/mL (10 mM) |
生物活性 | |
靶点 |
EGFR
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In vitro(体外研究) |
(-)-Epigallocatechin Gallate (EGCG) inhibits activation EGFR, HER2 and HER3 in the SW837 human colon cancer cell line. (-)-Epigallocatechin Gallate (10 μM) also inhibits cell growth, suppresses activation of EGFR, HER2, and HER3, and causes decrease in the levels of COX-2 and Bcl-xL proteins, and apoptosis after treatment for 96 h. (-)-Epigallocatechin Gallate (0-35 μg/mL) inhibits the proliferation of colorectal cancer cells. (-)-Epigallocatechin Gallate (35 μg/mL) induces apoptosis of colorectal cancer cells. (-)-Epigallocatechin Gallate (EGCG; 50, 75 and 100 μM) dose-dependently inhibits the growth of HepG2 cells, and induces apoptosis in HepG2 cells.
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In vivo(体内研究) |
(-)-Epigallocatechin Gallate (5, 10, and 20 mg/kg, p.o.) inhibits the growth of orthotopic colorectal cancer cells in mice.
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分子结构图