PD 198306CAS号： 212631-61-3分子式： C18H16F3IN2O2分子量： 476.2描述纯度储存/保存方法形态外观密度熔点沸点折射率IC50可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
PD 198306 is a cell-permeable amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk’s, and PI 3-Kγ (IC50 >1.0 μM). |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 形态 |
Solid
|
| 基本信息 | |
| 外观 |
White solid
|
| 密度 |
~1.7 g/cm3 (Predicted)
|
| 熔点 |
218.74° C (Predicted)
|
| 沸点 |
513.15° C (Predicted)
|
| 折射率 |
n20D 1.63 (Predicted)
|
| IC50 |
MEK1/2: IC50 = 8 nM; ERK: IC50 = > 1 µM; c-Src: IC50 = > 4 µM; cdks: IC50 = >4 µM; PI 3-kinase γ : IC50 = >10 µM
|
| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and ethanol (100 mM).
|
| PubChem CID |
9956637
|
分子结构图
