RO-5963CAS号： 1416663-77-8分子式： C24H21ClF2N4O5分子量： 518.9描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:50 mg/mL (96.36 mM)
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| 生物活性 | |
| 靶点 |
p53-MDMX:~24 nM, p53-MDM2:~17 nM
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| In vitro(体外研究) |
RO-5963 (10 μM, 24 hours) potently activates p53 and elevates p21 and MDM2 levels. RO-5963 (10-20 μM; 48 hours) displays much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines [1].
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