GSK963 CAS号： 2049868-46-2分子式： C14H18N2O分子量： 230.31描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GSK963 is a chiral small-molecule inhibitor of RIP1 kinase with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
GSK-963;GSK 963;GSK’963
|
| 外观 |
powder
|
| 可溶性/溶解性 |
DMSO ：46 mg/mL (199.73 mM)
|
| 生物活性 | |
| 靶点 |
RIP1 kinase
|
| In vitro(体外研究) |
GSK963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4 nM in human and murine cells.
|
| In vivo(体内研究) |
GSK963 is a potent inhibitor of a TNF+zVAD-mediated lethal shock. At 2 mg/kg, GSK963 would maintain blood concentrations above the concentration required for 90% inhibition of RIP1 activity for an extended period of time compared with Nec-1.
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分子结构图
