MCC-950 sodiumCAS号： 256373-96-3分子式： C20H23N2NaO5S分子量： 426.46描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
CP-456773 sodium；CRID3 sodium salt； MCC950 sodium；CP456773 sodium；CRID-3 sodium salt
|
| 外观 |
white to beige Powder
|
| 可溶性/溶解性 |
DMSO ：42.7 mg/mL (100 mM)
Water ：42.7 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 |
NLRP3
|
| In vitro(体外研究) |
MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.
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| In vivo(体内研究) |
MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.
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分子结构图
