LY-2940094CAS号： 1307245-86-8分子式： C22H23ClF2N4O2S分子量： 480.96描述纯度储存/保存方法别名可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
LY-2940094 is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY-2940094 reduces ethanol self-administration in animal models.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
BTRX-246040
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| 可溶性/溶解性 |
DMSO : 41.67 mg/mL (86.64 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
NOP receptor
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| In vivo(体内研究) |
LY2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity.
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分子结构图
