SR9243CAS号： 1613028-81-1分子式： C31H32BrN04S2分子量： 626.62描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SR9243 is a new inhibitor of The nuclear receptor liver-X-receptor (LXR),inducing LXR-corepressor interaction.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
SR 9243,SR9243,SR-9243
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMF 98 mg/mL warmed (156.39 mM)
DMSO <1 mg> |
| 生物活性 | |
| 靶点 |
LXR
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| In vitro(体外研究) |
In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments.
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| In vivo(体内研究) |
In Ob/Ob mice fed a high-fat diet, SR9243 (60 mg/kg, i.p.) inhibits LXR-dependent lipogenic enzyme gene expression and tumor growth.
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分子结构图
