LP-922056CAS号： 1365060-22-5分子式： C11H9ClN2O2S2分子量： 300.78描述储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO:120 mg/mL (398.96 mM)
|
| 生物活性 | |
| 靶点 |
human Notum Pectinacetylesterase:21 nM (EC50), mouse Notum Pectinacetylesterase:55 nM (EC50)
|
| In vitro(体外研究) |
LP-922056 can be used as a complementary chemical tool for exploring the role of Notum in Wnt signaling[2].
|
| In vivo(体内研究) |
In mice, LP-922056 (3, 10, 30 mg/kg; gavage) significantly increases midshaft femur cortical bone thickness. LP-922056 (10 mg/kg) achieved high Cmax of 129 μM and AUC of 1533 μM•h while volume of distribution is 0.13 L/kg and low clearance is 0.49 mL/min•kg[1]. LP-922056 (10 mg/kg; oral) increases cortical bone thickness and strength in the midshaft femur, bone mass in the femoral neck, and vertebral body cortical shell[2].
|