ZINC12409120 is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:α-Klotho interaction.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

ERK:5 μM

ZINC12409120 (1 nM-0.1 mM; 5 h) inhibits ERK reporter activities mediated by FGF23 (1 μM), with an IC50 of 5 μM.[1]
ZINC12409120 (10 μM; 5 h) specifically inhibits ERK activity mediated by FGF23:α-Klotho instead of EGF-mediated ERK activation and exhibits no inhibitory effect on EGFR tyrosine kinase or EGF/EGFR interaction.[1]