ONX-0912(Oprozomib)CAS号： 935888-69-0分子式： C25H32N4O7S分子量： 532.61描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
Oprozomib;ONX-0912; ONX0912; ONX 0912; PR-047; PR047; PR 047
|
| 外观 |
白色至类白色粉末
|
| 可溶性/溶解性 |
DMSO : 93 mg/mL (174.6 mM)
|
| 生物活性 | |
| 靶点 |
20S proteasome β5,20S proteasome LMP7
|
| In vitro(体外研究) |
The anti-MM activity of Oprozomib is associated with activation of caspase-8, caspase-9, caspase-3, and PARP, as well as inhibition of migration of MM cells and angiogenesis.
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| In vivo(体内研究) |
Oprozomib is demonstrated an JPolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80% proteasome inhibition in most tissues and elicited an antitumor response in multiple human tumor xenograft and mouse syngeneic models .
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分子结构图
