IPI-9119CAS号： 1346564-56-4分子式： C24H19F2N5O5分子量： 495.43描述储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:95 mg/mL (191.75 mM)
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| 生物活性 | |
| 靶点 |
FASN:0.3 nM (IC50)
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| In vitro(体外研究) |
IPI-9119 (0.05, 0.1, 0.25, 0.5, 5 μM; 6 days) inhibits AR-FL and AR-V7 protein expression. IPI-9119 (0.1, 0.5 μM; 6 days) inhibits cell growth and induces cell cycle arrest and apoptosis[1]. IPI-9119 inhibits FASN in cellular occupancy assays (IC50∼10nM) and shows more than 400-fold selectivity against several additional serine hydrolases[2].
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| In vivo(体内研究) |
IPI-9119 inhibits tumor growth of castration-resistant prostate cancer in xenografts mouse models[1].
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