CBS9106CAS号： 1076235-04-5分子式： C18H21ClF3N3O3分子量： 419.83描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
10 mM in DMSO
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| 生物活性 | |
| 靶点 |
CRM1
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| In vitro(体外研究) |
CBS9106 (0.01-10 μM; 72 hours) sensitizes cells to radiation and to suppress the growth of a variety of cancer cell lines. The estimated IC50 values range from 22.3 or 35.6 nM in multiple myeloma (MM).1S or RPMI-8226 cells and from 3 to 278 nM in 60 other human cancer cell lines.CBS9106 (1-400 nM; 24 hours) decreases CRM1 protein expression levels in a dose-dependent manner.Cell Viability AssayCell Line:MM.1S cells, RPMI-8226 cells Concentration:0.01, 0.1, 10 μMIncubation Time:72 hoursResult:Suppressed the growth of a variety of cancer cell lines and the estimated IC50 values ranged from 22.3 or 35.6 nM in MM.1S or RPMI-8226 cells.
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| In vivo(体内研究) |
CBS9106 (0.01-10 μM; 72 hours) sensitizes cells to radiation and to suppress the growth of a variety of cancer cell lines. The estimated IC50 values range from 22.3 or 35.6 nM in multiple myeloma (MM).1S or RPMI-8226 cells and from 3 to 278 nM in 60 other human cancer cell lines.CBS9106 (1-400 nM; 24 hours) decreases CRM1 protein expression levels in a dose-dependent manner.Cell Viability AssayCell Line:MM.1S cells, RPMI-8226 cells Concentration:0.01, 0.1, 10 μMIncubation Time:72 hoursResult:Suppressed the growth of a variety of cancer cell lines and the estimated IC50 values ranged from 22.3 or 35.6 nM in MM.1S or RPMI-8226 cells.
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