BMS-191095CAS号： 166095-21-2分子式： C22H21ClN4O2分子量： 408.88描述储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO:90 mg/mL (220.11 mM)
|
| 生物活性 | |
| In vitro(体外研究) |
BMS-191095 elicits a dose-dependent vasodilation in endothelium-denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. BMS-191095 induces mitochondrial-depolarization and vasodilation.
|
| In vivo(体内研究) |
In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
|