Eliglustat(Genz-99067)CAS号： 491833-29-5分子式： C23H36N2O4分子量： 404.54描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
Genz-99067; Genz99067; Genz 99067; Eliglustat Tartrate; GENZ-112638
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| 外观 |
Powder
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| 可溶性/溶解性 |
10 mM in DMSO
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| 生物活性 | |
| 靶点 |
glucosylceramide synthase
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| In vitro(体外研究) |
Eliglustat tartrate is designed and developed to inhibit glucosylceramide synthase, the enzyme that catalyzes the formation of glucosylceramide from UDP-glucose and ceramide.The inhibition of glucosylceramide synthase by eliglustat tartrate is highly specific. Eliglustat tartrate displays limited or no activity against a variety of glycosidases. Additionally, no inhibition of sucrase or maltase is observed at drug concentrations up to 10 μM.
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| In vivo(体内研究) |
Preclinical studies in normal mice, rats and dogs with i.v. and oral administration demonstrates significant dose-related decreases in spleen, kidney and liver glucosylceramide content, consistent with prior observations with the palmitoyl homologue.In rodents, Genz-112638 is rapidly metabolized with a half-life of 15–45 minutes.
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分子结构图
