LY2090314CAS号： 603288-22-8分子式： C28H25FN6O3分子量： 512.53描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
LY 2090314；LY-2090314
|
| 外观 |
yellow to orange powder
|
| 可溶性/溶解性 |
DMSO : 93 mg/mL (181.5 mM)
Ethanol : 2 mg/mL warmed (3.9 mM) |
| 生物活性 | |
| 靶点 |
GSK-3β；GSK-3α
|
| In vitro(体外研究) |
LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.
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| In vivo(体内研究) |
LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts.
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分子结构图
