AGK2CAS号： 304896-28-4分子式： C23H13Cl2N3O2分子量： 434.27描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
AGK2是一个有效的选择性SIRT2抑制剂，IC50值为3.5 μM。 |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
AGK-2
|
| 外观 |
yellow
|
| 可溶性/溶解性 |
DMSO : 4.3 mg/mL (10 mM)
|
| 生物活性 | |
| 靶点 |
SIRT2
|
| In vitro(体外研究) |
In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability.
|
| In vivo(体内研究) |
In drosophila model of parkinson’s disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation.
|
| 参考文献 | |
| 参考文献 |
[1] Outeiro TF, et al. Science.?007, 317(5837), 516-519. [2] He X, et al. Biochem Biophys Res Commun. 2012, 417(1), 468-472. [3] Petrilli A, et al. Oncotarget. 2013, 4(12), 2354-2365. |
分子结构图
